self-programming script in Search Results


imaris 8 1  (Oxford Instruments)
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Oxford Instruments imaris 8 1
Imaris 8 1, supplied by Oxford Instruments, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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function 'fminsearch  (MathWorks Inc)
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MathWorks Inc function 'fminsearch
Function 'fminsearch, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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matlab self-programmed script  (MathWorks Inc)
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MathWorks Inc matlab self-programmed script
Matlab Self Programmed Script, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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self-programming script in  (MathWorks Inc)
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MathWorks Inc self-programming script in
Self Programming Script In, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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spike2 analysis software  (Cambridge Electronic Design)
90
Cambridge Electronic Design spike2 analysis software
OR51E1-activation induces negative chronotropic effects in stem cell-derived cardiomyocytes. a Representative Ca 2+ imaging trace of a Fura-2-loaded human-induced pluripotent stem cell-derived cardiomyocyte (hIPS-CM). Cytosolic Ca 2+ levels were monitored as the integrated f 340 / f 380 fluorescence ratio expressed as a function of time. Horizontal bars indicate time and duration of stimulus application. In a randomly selected field of view, application of nonanoic acid inhibited spontaneous Ca 2+ transients in a dose-dependent manner. Carbachol (10 µM) served as positive control for negative chronotropy. b Statistical analysis of the effect of nonanoic acid (500 µM) on intracellular Ca 2+ dynamics of cardiomyocytes. Relevant parameters of the Ca 2+ transients during stimulus application were quantified by <t>Spike2</t> and normalized to the basal value. Analysis of the resulting Ca 2+ transients revealed that the frequency, time to peak, decay 50 and peak duration were significantly altered during nonanoic acid stimulation. The mean baseline, amplitude, v max peak and v min peak remain unchanged. Means were averaged from 25 to 37 experiments. Error bars represent the SEM. Significance was calculated by Student’s t test or Mann–Whitney U test (* p < 0.05, ** p < 0.01 and *** p < 0.001). c Nonanoic acid-induced negative chronotropy is cell type-independent. Ca 2+ spike frequency of iCell ® -CMs, hIPS-CMs and HES2-CMs decreases in a dose-dependent manner up to approximately 60%. The graph shows the percentage change in the frequency from the basal value. Means were averaged from 5 to 37 experiments. d Negative chronotropic effect of iCell ® -CMs to OR51E1 ligands: decanoic, dodecanoic and tetradecanoic acid. The data are shown as the mean ± SEM ( n > 29)
Spike2 Analysis Software, supplied by Cambridge Electronic Design, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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r-script  (RStudio)
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RStudio r-script
OR51E1-activation induces negative chronotropic effects in stem cell-derived cardiomyocytes. a Representative Ca 2+ imaging trace of a Fura-2-loaded human-induced pluripotent stem cell-derived cardiomyocyte (hIPS-CM). Cytosolic Ca 2+ levels were monitored as the integrated f 340 / f 380 fluorescence ratio expressed as a function of time. Horizontal bars indicate time and duration of stimulus application. In a randomly selected field of view, application of nonanoic acid inhibited spontaneous Ca 2+ transients in a dose-dependent manner. Carbachol (10 µM) served as positive control for negative chronotropy. b Statistical analysis of the effect of nonanoic acid (500 µM) on intracellular Ca 2+ dynamics of cardiomyocytes. Relevant parameters of the Ca 2+ transients during stimulus application were quantified by <t>Spike2</t> and normalized to the basal value. Analysis of the resulting Ca 2+ transients revealed that the frequency, time to peak, decay 50 and peak duration were significantly altered during nonanoic acid stimulation. The mean baseline, amplitude, v max peak and v min peak remain unchanged. Means were averaged from 25 to 37 experiments. Error bars represent the SEM. Significance was calculated by Student’s t test or Mann–Whitney U test (* p < 0.05, ** p < 0.01 and *** p < 0.001). c Nonanoic acid-induced negative chronotropy is cell type-independent. Ca 2+ spike frequency of iCell ® -CMs, hIPS-CMs and HES2-CMs decreases in a dose-dependent manner up to approximately 60%. The graph shows the percentage change in the frequency from the basal value. Means were averaged from 5 to 37 experiments. d Negative chronotropic effect of iCell ® -CMs to OR51E1 ligands: decanoic, dodecanoic and tetradecanoic acid. The data are shown as the mean ± SEM ( n > 29)
R Script, supplied by RStudio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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abactmat  (Abaqus Inc)
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Abaqus Inc abactmat
OR51E1-activation induces negative chronotropic effects in stem cell-derived cardiomyocytes. a Representative Ca 2+ imaging trace of a Fura-2-loaded human-induced pluripotent stem cell-derived cardiomyocyte (hIPS-CM). Cytosolic Ca 2+ levels were monitored as the integrated f 340 / f 380 fluorescence ratio expressed as a function of time. Horizontal bars indicate time and duration of stimulus application. In a randomly selected field of view, application of nonanoic acid inhibited spontaneous Ca 2+ transients in a dose-dependent manner. Carbachol (10 µM) served as positive control for negative chronotropy. b Statistical analysis of the effect of nonanoic acid (500 µM) on intracellular Ca 2+ dynamics of cardiomyocytes. Relevant parameters of the Ca 2+ transients during stimulus application were quantified by <t>Spike2</t> and normalized to the basal value. Analysis of the resulting Ca 2+ transients revealed that the frequency, time to peak, decay 50 and peak duration were significantly altered during nonanoic acid stimulation. The mean baseline, amplitude, v max peak and v min peak remain unchanged. Means were averaged from 25 to 37 experiments. Error bars represent the SEM. Significance was calculated by Student’s t test or Mann–Whitney U test (* p < 0.05, ** p < 0.01 and *** p < 0.001). c Nonanoic acid-induced negative chronotropy is cell type-independent. Ca 2+ spike frequency of iCell ® -CMs, hIPS-CMs and HES2-CMs decreases in a dose-dependent manner up to approximately 60%. The graph shows the percentage change in the frequency from the basal value. Means were averaged from 5 to 37 experiments. d Negative chronotropic effect of iCell ® -CMs to OR51E1 ligands: decanoic, dodecanoic and tetradecanoic acid. The data are shown as the mean ± SEM ( n > 29)
Abactmat, supplied by Abaqus Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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matlab r2021a  (MathWorks Inc)
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MathWorks Inc matlab r2021a
OR51E1-activation induces negative chronotropic effects in stem cell-derived cardiomyocytes. a Representative Ca 2+ imaging trace of a Fura-2-loaded human-induced pluripotent stem cell-derived cardiomyocyte (hIPS-CM). Cytosolic Ca 2+ levels were monitored as the integrated f 340 / f 380 fluorescence ratio expressed as a function of time. Horizontal bars indicate time and duration of stimulus application. In a randomly selected field of view, application of nonanoic acid inhibited spontaneous Ca 2+ transients in a dose-dependent manner. Carbachol (10 µM) served as positive control for negative chronotropy. b Statistical analysis of the effect of nonanoic acid (500 µM) on intracellular Ca 2+ dynamics of cardiomyocytes. Relevant parameters of the Ca 2+ transients during stimulus application were quantified by <t>Spike2</t> and normalized to the basal value. Analysis of the resulting Ca 2+ transients revealed that the frequency, time to peak, decay 50 and peak duration were significantly altered during nonanoic acid stimulation. The mean baseline, amplitude, v max peak and v min peak remain unchanged. Means were averaged from 25 to 37 experiments. Error bars represent the SEM. Significance was calculated by Student’s t test or Mann–Whitney U test (* p < 0.05, ** p < 0.01 and *** p < 0.001). c Nonanoic acid-induced negative chronotropy is cell type-independent. Ca 2+ spike frequency of iCell ® -CMs, hIPS-CMs and HES2-CMs decreases in a dose-dependent manner up to approximately 60%. The graph shows the percentage change in the frequency from the basal value. Means were averaged from 5 to 37 experiments. d Negative chronotropic effect of iCell ® -CMs to OR51E1 ligands: decanoic, dodecanoic and tetradecanoic acid. The data are shown as the mean ± SEM ( n > 29)
Matlab R2021a, supplied by MathWorks Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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selfprogrammed python scripts  (Abaqus Inc)
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Abaqus Inc selfprogrammed python scripts
OR51E1-activation induces negative chronotropic effects in stem cell-derived cardiomyocytes. a Representative Ca 2+ imaging trace of a Fura-2-loaded human-induced pluripotent stem cell-derived cardiomyocyte (hIPS-CM). Cytosolic Ca 2+ levels were monitored as the integrated f 340 / f 380 fluorescence ratio expressed as a function of time. Horizontal bars indicate time and duration of stimulus application. In a randomly selected field of view, application of nonanoic acid inhibited spontaneous Ca 2+ transients in a dose-dependent manner. Carbachol (10 µM) served as positive control for negative chronotropy. b Statistical analysis of the effect of nonanoic acid (500 µM) on intracellular Ca 2+ dynamics of cardiomyocytes. Relevant parameters of the Ca 2+ transients during stimulus application were quantified by <t>Spike2</t> and normalized to the basal value. Analysis of the resulting Ca 2+ transients revealed that the frequency, time to peak, decay 50 and peak duration were significantly altered during nonanoic acid stimulation. The mean baseline, amplitude, v max peak and v min peak remain unchanged. Means were averaged from 25 to 37 experiments. Error bars represent the SEM. Significance was calculated by Student’s t test or Mann–Whitney U test (* p < 0.05, ** p < 0.01 and *** p < 0.001). c Nonanoic acid-induced negative chronotropy is cell type-independent. Ca 2+ spike frequency of iCell ® -CMs, hIPS-CMs and HES2-CMs decreases in a dose-dependent manner up to approximately 60%. The graph shows the percentage change in the frequency from the basal value. Means were averaged from 5 to 37 experiments. d Negative chronotropic effect of iCell ® -CMs to OR51E1 ligands: decanoic, dodecanoic and tetradecanoic acid. The data are shown as the mean ± SEM ( n > 29)
Selfprogrammed Python Scripts, supplied by Abaqus Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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OR51E1-activation induces negative chronotropic effects in stem cell-derived cardiomyocytes. a Representative Ca 2+ imaging trace of a Fura-2-loaded human-induced pluripotent stem cell-derived cardiomyocyte (hIPS-CM). Cytosolic Ca 2+ levels were monitored as the integrated f 340 / f 380 fluorescence ratio expressed as a function of time. Horizontal bars indicate time and duration of stimulus application. In a randomly selected field of view, application of nonanoic acid inhibited spontaneous Ca 2+ transients in a dose-dependent manner. Carbachol (10 µM) served as positive control for negative chronotropy. b Statistical analysis of the effect of nonanoic acid (500 µM) on intracellular Ca 2+ dynamics of cardiomyocytes. Relevant parameters of the Ca 2+ transients during stimulus application were quantified by Spike2 and normalized to the basal value. Analysis of the resulting Ca 2+ transients revealed that the frequency, time to peak, decay 50 and peak duration were significantly altered during nonanoic acid stimulation. The mean baseline, amplitude, v max peak and v min peak remain unchanged. Means were averaged from 25 to 37 experiments. Error bars represent the SEM. Significance was calculated by Student’s t test or Mann–Whitney U test (* p < 0.05, ** p < 0.01 and *** p < 0.001). c Nonanoic acid-induced negative chronotropy is cell type-independent. Ca 2+ spike frequency of iCell ® -CMs, hIPS-CMs and HES2-CMs decreases in a dose-dependent manner up to approximately 60%. The graph shows the percentage change in the frequency from the basal value. Means were averaged from 5 to 37 experiments. d Negative chronotropic effect of iCell ® -CMs to OR51E1 ligands: decanoic, dodecanoic and tetradecanoic acid. The data are shown as the mean ± SEM ( n > 29)

Journal: Basic Research in Cardiology

Article Title: Medium-chain fatty acids modulate myocardial function via a cardiac odorant receptor

doi: 10.1007/s00395-017-0600-y

Figure Lengend Snippet: OR51E1-activation induces negative chronotropic effects in stem cell-derived cardiomyocytes. a Representative Ca 2+ imaging trace of a Fura-2-loaded human-induced pluripotent stem cell-derived cardiomyocyte (hIPS-CM). Cytosolic Ca 2+ levels were monitored as the integrated f 340 / f 380 fluorescence ratio expressed as a function of time. Horizontal bars indicate time and duration of stimulus application. In a randomly selected field of view, application of nonanoic acid inhibited spontaneous Ca 2+ transients in a dose-dependent manner. Carbachol (10 µM) served as positive control for negative chronotropy. b Statistical analysis of the effect of nonanoic acid (500 µM) on intracellular Ca 2+ dynamics of cardiomyocytes. Relevant parameters of the Ca 2+ transients during stimulus application were quantified by Spike2 and normalized to the basal value. Analysis of the resulting Ca 2+ transients revealed that the frequency, time to peak, decay 50 and peak duration were significantly altered during nonanoic acid stimulation. The mean baseline, amplitude, v max peak and v min peak remain unchanged. Means were averaged from 25 to 37 experiments. Error bars represent the SEM. Significance was calculated by Student’s t test or Mann–Whitney U test (* p < 0.05, ** p < 0.01 and *** p < 0.001). c Nonanoic acid-induced negative chronotropy is cell type-independent. Ca 2+ spike frequency of iCell ® -CMs, hIPS-CMs and HES2-CMs decreases in a dose-dependent manner up to approximately 60%. The graph shows the percentage change in the frequency from the basal value. Means were averaged from 5 to 37 experiments. d Negative chronotropic effect of iCell ® -CMs to OR51E1 ligands: decanoic, dodecanoic and tetradecanoic acid. The data are shown as the mean ± SEM ( n > 29)

Article Snippet: The data for Fura-2 calcium transients were analyzed with a self-written script in Spike2 ® analysis software (Cambridge Electronic Design, Cambridge, UK) and partly by Chart5 ® (ADInstruments, Oxford, UK, http://www.adinstruments.com ).

Techniques: Activation Assay, Derivative Assay, Imaging, Fluorescence, Positive Control, MANN-WHITNEY